Travelers Diarrhea

Travelers Diarrhea is experienced when eating, drinking from a location with different bacteria and foods, further than 200-500 miles from home.

There are two types of traveler's diarrhea, one is from experiencing new bacterias and microbes. The other is from eating too much of a strange food, say too many mango's, but normally falsely blamed on the water.

People who eat in large tourist restaurants contract this often because you cannot see how the food is cooked, it is best to eat street food.

Traveler's tummy

Traveler's diarrhea Defined:

"Montezuma's revenge" or "Traveler's Tummy."

Traveler's diarrhea (TD), is the most common illness affecting travelers. An estimated 10 million people—20% to 50% of international travelers—develop it annually. TD is defined as three or more unformed stools in 24 hours passed by a traveler, commonly accompanied by abdominal cramps, nausea, and bloating. It does not imply a specific organism, but Enterotoxigenic Escherichia coli is the most common. Most cases are self-limited and the pathogen is usually not identified.  

Signs and symptoms   The onset of TD usually occurs within the first week of travel, but may occur at any time while traveling, and even after returning home. When it appears depends in part on the specific infectious agent. The incubation period for giardiasis averages about 14 days and that of cryptosporidiosis about seven days. Certain other bacterial and viral agents have shorter incubation periods, although hepatitis may take weeks to manifest itself. Most TD cases begin abruptly.   Typically, a traveler experiences four to five loose or watery bowel movements each day. Other commonly associated symptoms are nausea, vomiting, diarrhea, abdominal cramping, bloating, low fever, urgency, and malaise, and appetite is usually low or nonexistent.   Blood or mucus in the diarrhea, abdominal pain, or high fever heralds a more serious cause, such as cholera, characterized by a rapid onset of symptoms including weakness, malaise, and torrents of watery diarrhea with flecks of mucus (described as "rice water" stools). Dehydration is a serious consequence of cholera; death may (rarely) occur as quickly as 24 hours after onset.  

Causes  

E. coli, enterotoxigenic   20-75%  

E. coli, enteroaggregative   0-20%  

E. coli, enteroinvasive   0-6%  

Shigella spp   2-30%  

Salmonella spp   0-33%  

Campylobacter jejuni   3-17%  

Vibrio parahemolyticus   0-31%  

Aeromonas hydrophila   0-30%  

Giardia lamblia   0 to less than 20%  

Entamoeba histolytica   0-5%  

Cryptosporidium sp   0 to less than 20%  

Rotavirus   0-36%  

Norwalk virus   0-10%  

Infectious agents are the primary cause of travelers' diarrhea. Bacterial enteropathogens cause approximately 80% of cases.   The most common causative agent isolated in countries surveyed has been enterotoxigenic Escherichia coli (ETEC). Enteroaggregative E. coli is increasingly recognized and many studies do not look for this important bacterium. Shigella spp. are the other most common bacteria involved. Incidents in which other bacteria, such as Salmonella, Campylobacter, Yersinia, Aeromonas, and Plesiomonas spp., have caused diarrhea are isolated and occur less often. Protozoan parasites such as Giardia lamblia and Cryptosporidium may also cause diarrhea.   Some bacteria release toxins which bind to the intestines and cause diarrhea; others damage the intestines themselves by their direct presence. In infants and children, it is estimated that nearly 70% of diarrhea is due to viruses; for adult travelers, this drops to around 30%. Diarrhea caused by viral agents is unaffected by antibiotic therapy, but is usually self-limited.   Pathogens implicated in travelers' diarrhea appear in the table at right.   A sub-type of traveler's diarrhea afflicting hikers and campers, sometimes known as wilderness diarrhea, may have a somewhat different frequency distribution of pathogens.   Risk factors   The primary source of infection is ingestion of fecally-contaminated food or water. Attack rates are similar for men and women.   The most important determinant of risk is the traveler's destination. High risk destinations include developing countries in Latin America, Africa, the Middle East, and Asia. Among backpackers, additional risk factors include drinking untreated surface water and failure to maintain personal hygiene practices and clean cookware. Campsites often have very primitive (if any) sanitation facilities, making them as potentially dangerous as any developing country.   Although traveler's diarrhea usually resolves within three to five days (mean duration: 3.6 days), in about 20% of cases the illness is severe enough to require bedrest, and in 10% the illness duration exceeds one week. For those prone to serious infections, such as bacillary dysentery, amoebic dysentery, and cholera, TD can occasionally be life-threatening. Others at higher-than-average risk include young adults, immunosuppressed persons, persons with inflammatory bowel disease or diabetes, and those taking H2 blockers or antacids.   Immunity   Travelers often get diarrhea from eating and drinking products that have no such effect on local residents. This is due to immunity that develops after repeated exposure to pathogens. It is not fully clear how much exposure is needed, and to what extent the immune system can become tolerant to pathogens, but a study among expatriates in Nepal suggests that it can take seven years to develop immunity—presumably in adults who avoid deliberate pathogen exposure. On the other hand, immunity that American students acquired while living in Mexico appeared to disappear within as little as 8 weeks of cessation of exposure.   Prevention   The best means of prevention is to avoid any questionable foods or beverages. Traveler's diarrhea is fundamentally a sanitation failure, leading to bacterial contamination of drinking water and food. It is best prevented through proper water quality management systems, as found in responsible hotels and resorts. In the absence of that, the next best option for travelers is to take individual precautions:  Drink safe beverages, which include bottled water, bottled carbonated beverages, hot tea or coffee, and water boiled or appropriately treated by the traveler. Caution should be exercised with hot beverages, which may be only heated, not boiled.  Maintain good hygiene and only use safe water for drinking and tooth brushing.  Avoid ice, which may not have been made with bottled water.  In restaurants, insist that bottled water be unsealed in your presence. Reports of locals filling empty bottles with untreated tap water and reselling them as purified water have come out of several countries. When in doubt, a bottled carbonated beverage is the safest choice, since it is almost impossible to "fake" carbonation when refilling a used bottle.  Avoid eating raw fruits and vegetables unless the traveler peels them personally.  Avoid green salads, because it is unlikely that the lettuce will have been washed with bottled water.   If handled properly, well-cooked and packaged foods are usually safe. Eating raw or undercooked meat and seafood should be avoided. Unpasteurized milk, dairy products, mayonnaise and pastry icing are associated with increased risk for TD, as are foods or drinking beverages purchased from street vendors or other establishments where unhygienic conditions may be present.   Active intervention involves boiling water for three to five minutes (depending on elevation), filtering water with appropriate filters or using chlorine bleach (2 drops per litre) or tincture of iodine (5 drops per litre) in the water. The wide availability of safe bottled water makes these interventions unnecessary for all but the most remote destinations.   An ultraviolet (UV) water purification device is available commercially that allows treatment of small amounts of water at room temperature. The UV light bonds DNA thymine rings, preventing the survival or replication of any infectious organisms in the water. UV light also kills viruses, which are not typically removed by filtration (although filtration is recommended prior to treatment if the water is visibly clouded). Other claimed advantages include no taste alteration, elimination of need for boiling, and decreased long-term cost compared with bottled water.   Other preventive measures include over-the-counter anti-diarrhea products and in certain situations, prophylactic medications and supplements. Studies show a decrease in the incidence of TD with use of bismuth subsalicylate and antimicrobial chemoprophylaxis.   Bismuth subsalicylate (two tablets or two ounces four times daily) will reduce the likelihood of travelers' diarrhea, but few travelers adhere to a four-times-per-day regimen because it is inconvenient. Side effects may include black tongue, black stools, nausea, constipation, and ringing in the ears (tinnitus). Bismuth subsalicylate should not be taken by those with aspirin allergy, kidney disease, or gout, nor concurrently with certain antibiotics, and should not be taken for more than three weeks.   Though effective, antibiotics are not recommended in most situations to prevent diarrhea before it occurs, because of the risk of adverse reactions to the antibiotics, and because intake of prophylactic antibiotics may decrease effectiveness of such drugs should a serious infection occur. Antibiotics can also cause vaginal yeast infections (which many women consider a worse problem than the diarrhea ). Also, antibiotics can cause a disease called pseudomembranous colitis which results in severe, unrelenting diarrhea.   However, prophylaxis may be warranted in special situations where benefits outweigh the above risks, such as immunocompromised travelers, chronic intestinal disorders, prior history of repeated disabling bouts of traveler's diarrhea, or scenarios in which onset of diarrhea might prove particularly troublesome. Options for prophylactic treatment include the quinolone antibiotics (norfloxacin, ciprofloxacin, ofloxacin, among others), and trimethoprim/sulfamethoxazole. Quinolone antibiotics may bind to metallic cations such as bismuth, and should not be taken concurrently with bismuth subsalicylate. Trimethoprim/sulfamethoxazole should not be taken by anyone with a history of sulfa allergy.   A few pathogen-specific vaccines have become available, and others are under development. Dukoral, an oral vaccine against Vibrio cholerae, has demonstrated up to 43% protective efficacy against TD when one dose is given a few weeks before travel and a second a week before travel, although it is not officially approved for that indication in most countries. Several vaccine candidates targeting enterotoxigenic E. coli and Shigella are in various stages of development.   A patch-delivered travelers’ diarrhea vaccine is under development by Iomai (which was acquired by Intercell in 2008 ). Results of a phase II clinical trial, published in 2008 in The Lancet, indicate significant protection from clinically significant diarrhea compared with placebo. The vaccine remains experimental, at the phase III clinical trial level, and is not yet licensed in any country. In 2009 a research group at the University of Guelph announced that it was working on a TD vaccine targeting Campylobacter jejuni. To date, no human clinical trials have been reported.   Travelan is a proprietary mix of antibodies against common strains of E.Coli involved in travellers diarrhea. The manufacturer claims that the antibodies inhibit ETEC attachment to the intestinal wall, and avoid killing beneficial flora because of their specificity to ETEC strains. When taken orally before every meal, the manufacturer claims prevention of TD "in up to 93% of volunteers", but no impartial placebo-controlled studies have been published. In 2010 the product underwent an FDA recall after it "...failed to meet stability specifications when assayed at approximately 3 months after being manufactured."   Two probiotics (Saccharomyces boulardii and a mixture of Lactobacillus acidophilus and Bifidobacterium bifidum) have been studied as a treatment for TD. In a meta-analysis by McFarland (2005), no serious adverse reactions were reported in 12 trials. These probiotics may offer a safe and effective method to prevent TD, but due to strain stability and survivability issues, they may not always be an appropriate choice. Prebiotics, as an alternative, are more stable than probiotics during passage through the upper gastrointestinal tract and are able to induce antimicrobial effects principally through their selective stimulation of our own beneficial gut bacteria. However, prebiotics act mainly in the large intestine, while the infective organisms causing TD act in the small intestine. Therefore, current prebiotics (such as fructooligosaccharide) have very limited application as preventative agents. Second generation prebiotic galactooligosaccharides, such as B-GOS (Bimuno), have additional properties such as positive effect on immunity and direct interaction with the host gut epithelium, preventing the attachment and invasion of gastrointestinal pathogens. B-GOS was shown to result in significant reduction in the incidence and duration of TD in a study with human volunteers travelling to countries with medium to high risk of developing TD.   Treatment   Most cases of TD are mild and do not require either antibiotics or antimotility drugs. Adequate fluid intake (oral rehydration therapy) is essential to replace lost fluids and electrolytes. Clear, disinfected water or other liquids are routinely recommended for adults. Water that is purified is best, along with oral rehydration salts to replenish lost electrolytes. Carbonated water (soda), which has been left out so that the carbonation fizz is gone, is useful if nothing else is available.   Antibiotics   If diarrhea becomes severe (typically defined as three or more loose stools in a 24-hour period) — or if diarrhea is bloody, or fever occurs with shaking chills, or abdominal pain becomes marked, or diarrhea persists for more than 72 hours — medical treatment should be sought. Such patients may benefit from antimicrobial therapy. Antibiotics are typically given for three to five days, but single doses of azithromycin or levofloxacin have been used. If diarrhea persists despite therapy, travelers should be evaluated for possible viral or parasitic infections, bacterial or amoebic dysentery, Giardia, helminths, or cholera.   Antimotility agents   Antimotility drugs such as loperamide and diphenoxylate reduce the symptoms of diarrhea by slowing transit time in the gut. They should be taken as necessary to slow the frequency of stools, but not enough to stop bowel movements completely, which delays expulsion of the causative organisms from the intestines. Adverse reactions may include nausea, vomiting, abdominal pain, hives or rash, and loss of appetite. Antimotility agents should not, as a rule, be given to children under age two.   Epidemiology   Each year 20%–50% of international travelers, or more than 15 million people annually get diarrhea. It is much more common in those who travel to the developing world rather than developed world with rates at more than 60% in the former.   Society and culture   There are a number of colloquialisms for travelers' diarrhea contracted in various localities, such as "Montezuma's revenge", "turistas", or "Aztec two step" for travelers' diarrhea contracted in Mexico, "Pharaoh's Revenge," "mummy's tummy," or "Cairo two-step" in Egypt, "Kurtz Hurtz" in Uzbekistan, "Bombay belly" or "Delhi belly" in India, "A case of the shits" or "Hershey Squirts" or "The McShits" in North America, "Down Under Butt Chunder" in Australia, "Karachi crouch" in Pakistan, "Suryavarman's Revenge" in Cambodia, "kabulitis" in Afghanistan, "holiday tummy" in United Kingdom, although this is not directed at tourists in the UK but at British tourists abroad, "Bali belly" in Bali, or "Taghazout Tummy" in Taghazout or "Kathmandu quickstep" in Nepal. In Canada it is termed "beaver fever". In China, diarrhea is referred to as ??? (pinyin: l? dùzi, lit.: "pulled stomach"). A recent local term in Pattaya, Thailand, is "Thai-dal wave". Peacekeepers to Arabic-speaking countries have called it "yalla yalla" (Arabic for "fast, fast") referring to the extreme urgency it causes. This one is similar to "corre corre" meaning "run run" used in some regions of Colombia.   The name Delhi Belly was used as the title of 2011 Hindi film, Delhi Belly, produced by Aamir Khan.   Montezuma's revenge   "Montezuma's revenge" redirects here. For other uses, see Montezuma's revenge (disambiguation).   Montezuma's revenge (var. Moctezuma's revenge) is the colloquial term for any cases of traveler's diarrhea contracted by tourists visiting Mexico. The name refers to Moctezuma II (1466–1520), the Tlatoani (ruler) of the Aztec civilization who was defeated by Hernán Cortés, the Spanish conquistador.   Most cases are mild and resolve in a few days without any treatment. Severe or extended cases, however, may result in extensive fluid loss and/or dangerous electrolytic imbalance which pose a severe medical risk and may prove fatal if mismanaged. The oversight of a medical professional is advised.   Wilderness diarrhea   Wilderness diarrhea (WD), also called wilderness-acquired diarrhea (WAD) or backcountry diarrhea, is the name preferred by some backpackers, hikers, campers and other outdoor recreationalists for traveler's diarrhea that appears in wilderness or "backcountry" situations while still in their home country. It is due to the same agents as all other traveler's diarrhea, which are usually bacterial and viral in short expeditions and may be giardiasis in longer expeditions. and is largely due to the absence of treated water and poor hygiene. Some people reserve the name backpacker's diarrhea as a synonym for giardiasis.





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